When you hold your breath, which of the following gas changes in blood would first lead to the urge to…

When you hold your breath, which of the following gas changes in blood would first lead to the urge to breathe?
A Falling $O_2$ concentration
B Rising $CO_2$ concentration
C Falling $CO_2$ concentration
D Rising $CO_2$ and falling $O_2$ concentration

Detailed Solution

Chemoreceptors in the medulla, aortic arch and carotid bodies sense $CO_2$, $O_2$ and pH of blood; $CO_2$ has the stronger effect.
Holding the breath raises blood $CO_2$, which stimulates breathing, so holding the breath beyond a point becomes impossible.

Regulation of respiration in past papers

2 questions from this chapter have appeared across 2 exam years.

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Practise Regulation of respiration All 2 questions This chapter in 2015 AIPMT-I