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A person suffering from a disease caused by $Plasmodium$ experiences recurring chill and fever at the time when
A
The sporozoites released from RBCs are being rapidly killed and broken down inside spleen
B
The trophozoites reach maximum growth and give out certain toxins
C
The parasite after its rapid multiplication inside RBCs ruptures them, releasing the stage to enter fresh RBCs
D
The microgametocytes and megagametocytes are being destroyed by the WBCs
Detailed Solution
$Plasmodium$ enters the body as sporozoites, which first multiply in the liver cells and then attack the red blood cells.
Inside the RBCs the parasite multiplies asexually; the RBCs then rupture, releasing the new parasites (merozoites) that enter fresh RBCs.
The rupture of RBCs is associated with the release of a toxic substance, haemozoin, which is responsible for the chill and high fever recurring every three to four days.
Sporozoites are not released from RBCs, and the destruction of gametocytes is not the cause of the fever.
Hence chill and fever occur when the parasite, after rapid multiplication inside RBCs, ruptures them and releases the stage that enters fresh RBCs.
Inside the RBCs the parasite multiplies asexually; the RBCs then rupture, releasing the new parasites (merozoites) that enter fresh RBCs.
The rupture of RBCs is associated with the release of a toxic substance, haemozoin, which is responsible for the chill and high fever recurring every three to four days.
Sporozoites are not released from RBCs, and the destruction of gametocytes is not the cause of the fever.
Hence chill and fever occur when the parasite, after rapid multiplication inside RBCs, ruptures them and releases the stage that enters fresh RBCs.