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Select the correct statements regarding mechanism of muscle contraction. A. It is initiated by a signal sent by CNS via sensory neuron. B. Neurotransmitter generates action potential in the sarcolemma. C. Increased $Ca^{++}$ level leads to the binding of calcium with troponin on action filaments. D. Masking of active site for actin is activated. E. Utilising the energy from ATP hydrolysis to form cross bridge. Choose the most appropriate answer from the options given below:
Detailed Solution
Muscle contraction is initiated by a signal sent by the CNS via a motor neuron (not a sensory neuron, so A is incorrect). The neurotransmitter (acetylcholine) released at the neuromuscular junction generates an action potential in the sarcolemma (B is correct). Increased $Ca^{2+}$ binds with troponin on actin filaments, which unmasks (not masks) the active sites for myosin (so D is incorrect as stated), and the myosin head uses energy from ATP hydrolysis to form cross bridges (E is correct). So the correct statements are B, C and E only.