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One gene-one enzyme relationship was established for the first time in
A
Salmonella typhimurium
B
Escherichia coli
C
Diplococcus pneumoniae
D
Neurospora crassa
Detailed Solution
The one gene-one enzyme hypothesis was given by the geneticists George W. Beadle and E. L. Tatum in 1941.
They worked on the pink bread mould Neurospora crassa.
They exposed it to X-rays to produce nutritional mutants (auxotrophs), which could grow only when a particular nutrient was added to the minimal medium.
Each mutant was found to lack one specific enzyme of a biosynthetic pathway, owing to a mutation in a single gene.
They concluded that each gene in an organism controls the production of a specific enzyme, and it is these enzymes that catalyse the reactions leading to the phenotype.
Diplococcus pneumoniae was used by Griffith for transformation, and Escherichia coli for the lac operon and for the Meselson-Stahl experiment.
So the relationship was first established in Neurospora crassa.
They worked on the pink bread mould Neurospora crassa.
They exposed it to X-rays to produce nutritional mutants (auxotrophs), which could grow only when a particular nutrient was added to the minimal medium.
Each mutant was found to lack one specific enzyme of a biosynthetic pathway, owing to a mutation in a single gene.
They concluded that each gene in an organism controls the production of a specific enzyme, and it is these enzymes that catalyse the reactions leading to the phenotype.
Diplococcus pneumoniae was used by Griffith for transformation, and Escherichia coli for the lac operon and for the Meselson-Stahl experiment.
So the relationship was first established in Neurospora crassa.