Study the pedigree chart given below:What does it show?

Study the pedigree chart given below:

What does it show?
A Inheritance of a recessive sex-linked disease like haemophilia
B Inheritance of a sex-linked inborn error of metabolism like phenylketonuria
C Inheritance of a condition like phenylketonuria as an autosomal recessive trait
D The pedigree chart is wrong as this is not possible

Detailed Solution

In the chart, unaffected parents have affected children; this is possible only if the trait is recessive and both parents are heterozygous carriers.
The affected individuals include a female born to an unaffected father. For an X-linked recessive trait an affected daughter ($X^aX^a$) must have an affected father ($X^aY$), so sex-linked inheritance like haemophilia is ruled out.
The trait is therefore autosomal recessive: carrier parents $Aa \times Aa$ give affected children (aa) of either sex.
Phenylketonuria is an inborn error of metabolism inherited as an autosomal recessive trait (it is not sex-linked).
Hence the chart shows inheritance of a condition like phenylketonuria as an autosomal recessive trait.

Pedigree Analysis in past papers

6 questions from this chapter have appeared across 5 exam years.

Keep going

Practise Pedigree Analysis All 6 questions This chapter in 2009 AIPMT