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The number of time(s) decarboxylation of isocitrate occurs during single TCA cycle is:
Detailed Solution
In a single Krebs cycle decarboxylation occurs at two steps: isocitrate is oxidatively decarboxylated to 5-C $\alpha$-ketoglutarate, and $\alpha$-ketoglutarate is decarboxylated to 4-C succinyl-CoA. Isocitrate itself is decarboxylated only once.