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G-6-P dehydrogenase deficiency is associated with haemolysis of -
A
Leucocytes
B
Lymphocytes
C
Platelets
D
RBCs
Detailed Solution
Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme of the pentose phosphate pathway, which produces NADPH.
In red blood cells this pathway is the only source of NADPH, which keeps glutathione in its reduced form; reduced glutathione protects the cells against damage by oxidising agents.
In G6PD deficiency (an X-linked recessive disorder) the RBCs cannot protect themselves from oxidative stress.
On exposure to certain drugs (such as primaquine and sulphonamides), infections or fava beans, the haemoglobin and membranes of the RBCs are damaged and the cells burst.
This haemolysis of red blood cells causes haemolytic anaemia.
So G6PD deficiency is associated with the haemolysis of RBCs.
In red blood cells this pathway is the only source of NADPH, which keeps glutathione in its reduced form; reduced glutathione protects the cells against damage by oxidising agents.
In G6PD deficiency (an X-linked recessive disorder) the RBCs cannot protect themselves from oxidative stress.
On exposure to certain drugs (such as primaquine and sulphonamides), infections or fava beans, the haemoglobin and membranes of the RBCs are damaged and the cells burst.
This haemolysis of red blood cells causes haemolytic anaemia.
So G6PD deficiency is associated with the haemolysis of RBCs.