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Digestion in stomach
Concepts tested here
- Parietal cells and HCl
All Questions
2010 AIPMT-MAINS 1 question
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If for some reason the parietal cells of the gut epithelium become partially non-functional, what is likely to happen?The gastric glands have three types of cells: mucus neck cells (mucus), peptic or chief cells (pepsinogen) and parietal or oxyntic cells (HCl and intrinsic factor).
HCl provides the acidic pH (about 1.8) that is optimal for pepsin, and it converts the proenzyme pepsinogen into active pepsin.
Pepsin converts proteins into proteoses and peptones.
If the parietal cells are partly non-functional, less HCl is secreted; the pH of the stomach rises (it does not fall), less pepsin is formed and it works poorly.
Trypsin, lipase and steapsin are pancreatic enzymes that act in the alkaline medium of the intestine and are not directly affected.
Hence proteins will not be adequately hydrolysed by pepsin into proteoses and peptones.