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Angiotensinogen is a protein produced and secreted by -
A
Macula densa cells
B
Endothelial cells (cells lining the blood vessels)
C
Liver cells
D
Juxtaglomerular (JG) cells
Detailed Solution
Angiotensinogen is a plasma protein produced and secreted into the blood by the liver cells.
When the glomerular blood flow or blood pressure falls, the juxtaglomerular (JG) cells of the kidney release the enzyme renin.
Renin converts angiotensinogen in the blood into angiotensin I.
Angiotensin I is converted into angiotensin II by the angiotensin converting enzyme, mainly in the lungs.
Angiotensin II is a powerful vasoconstrictor; it raises the glomerular blood pressure and stimulates the adrenal cortex to release aldosterone.
So the JG cells secrete renin, not angiotensinogen, and the macula densa cells only sense the composition of the filtrate.
Angiotensinogen is produced and secreted by the liver cells.
When the glomerular blood flow or blood pressure falls, the juxtaglomerular (JG) cells of the kidney release the enzyme renin.
Renin converts angiotensinogen in the blood into angiotensin I.
Angiotensin I is converted into angiotensin II by the angiotensin converting enzyme, mainly in the lungs.
Angiotensin II is a powerful vasoconstrictor; it raises the glomerular blood pressure and stimulates the adrenal cortex to release aldosterone.
So the JG cells secrete renin, not angiotensinogen, and the macula densa cells only sense the composition of the filtrate.
Angiotensinogen is produced and secreted by the liver cells.