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In higher vertebrates, the immune system can distinguish self-cells and non-self. If this property is lost due to genetic abnormality and it attacks self-cells, then it leads to
A
graft rejection.
B
auto-immune disease.
C
active immunity.
D
allergic response.
Explanation
Attack on self-cells = autoimmunity.
Detailed Solution
If the ability to distinguish self from non-self is lost due to genetic disorders, the immune system attacks self-cells. This is called auto-immune disease, e.g. rheumatoid arthritis.