Immunity – Autoimmunity

Given below are two statements: Statement I: Autoimmune disorder is a condition where body defense mechanism recognizes its own cells as foreign bodies. Statement II: Rheumatoid arthritis is a condition where body does not attack self cells. In the light of the above statements, choose the most appropriate answer from the options given below.

In higher vertebrates, the immune system can distinguish self-cells and non-self. If this property is lost due to genetic abnormality and it attacks self-cells, then it leads to