Changes in GnRH pulse frequency in females is controlled by circulating levels of

Changes in GnRH pulse frequency in females is controlled by circulating levels of
A estrogen and inhibin.
B progesterone only.
C progesterone and inhibin.
D estrogen and progesterone.

Explanation

Ovarian steroids (estrogen and progesterone) feed back on GnRH pulses.

Detailed Solution

At puberty, GnRH stimulates the anterior pituitary to secrete FSH and LH, which stimulate follicular growth and estrogen secretion.
Rising estrogen gives negative feedback on FSH and LH secretion. After ovulation, the corpus luteum secretes large amounts of progesterone.
Both estrogen and progesterone change the GnRH pulse frequency in females during every menstrual cycle.

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