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Neurotransmitters and Brain Disorders
Concepts tested here
- Dopamine and Parkinson's disease
All Questions
2005 AIPMT 1 question
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Parkinson's disease (characterized by tremors and progressive rigidity of limbs) is caused by degeneration of brain neurons that are involved in movement control and make use of neurotransmitter -Parkinson's disease is a degenerative disorder of the brain, marked by tremors, rigidity of the limbs and slowness of movement.
It is caused by the degeneration of the dopamine-producing neurons of the substantia nigra in the midbrain.
These neurons send fibres to the basal ganglia (corpus striatum), which help to control and smooth out body movements.
With the loss of dopamine, this control is disturbed and the characteristic symptoms appear.
The disease is treated with L-dopa, a precursor that is converted into dopamine in the brain.
So the neurotransmitter involved is dopamine.