2026 Principles of Inheritance and VariationSickle-cell anaemia - point mutation Easy Question 1 of 198 in Principles of Inheritance and Variation

Which one of the following disorders is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule?

A Haemophilia
B Thalassemia
C Sickle-cell anaemia
D Phenylketonuria

The answer is C.

Principles of Inheritance and Variation in past papers

198 questions from this chapter have appeared across 27 exam years.