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Which one of the following statements is incorrect?
A
A competitive inhibitor reacts reversibly with the enzyme to form an enzyme–inhibitor complex
B
In competitive inhibition, the inhibitor molecule is not chemically changed by the enzyme
C
The competitive inhibitor does not affect the rate of breakdown of the enzyme–substrate complex
D
The presence of the competitive inhibitor decreases the Km of the enzyme for the substrate
Detailed Solution
A competitive inhibitor increases the $K_m$ of the enzyme: a higher substrate concentration is needed to reach $\frac{1}{2}V_{max}$.
So the statement that it decreases $K_m$ is incorrect.
So the statement that it decreases $K_m$ is incorrect.