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Select the option which is not correct with respect to enzyme action:
A
Substrate binds with enzyme at its active site
B
Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate
C
A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate
D
Malonate is a competitive inhibitor of succinic dehydrogenase
Detailed Solution
Malonate resembles succinate and competes with it for the active site of succinic dehydrogenase (competitive inhibition).
Competitive inhibition is reversed by adding excess substrate, so the statement that excess succinate does not reverse it is not correct.
Competitive inhibition is reversed by adding excess substrate, so the statement that excess succinate does not reverse it is not correct.