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Which one of the following is not a second messenger in hormone action ?
A
cGMP
B
Calcium
C
Sodium
D
cAMP
Detailed Solution
Peptide, protein and catecholamine hormones cannot enter the target cell; they bind to membrane-bound receptors on its surface.
The hormone is the first messenger. Its binding to the receptor generates a second messenger inside the cell, which carries the message further and regulates cellular metabolism.
The common second messengers are cyclic AMP (cAMP), cyclic GMP (cGMP), inositol triphosphate ($IP_3$) and calcium ions ($Ca^{2+}$).
Sodium ions are important for the membrane potential and the nerve impulse, but they do not act as a second messenger in hormone action.
So the one that is not a second messenger is sodium.
The hormone is the first messenger. Its binding to the receptor generates a second messenger inside the cell, which carries the message further and regulates cellular metabolism.
The common second messengers are cyclic AMP (cAMP), cyclic GMP (cGMP), inositol triphosphate ($IP_3$) and calcium ions ($Ca^{2+}$).
Sodium ions are important for the membrane potential and the nerve impulse, but they do not act as a second messenger in hormone action.
So the one that is not a second messenger is sodium.