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Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis ?
A
Erythromycin
B
Neomycin
C
Streptomycin
D
Tetracycline
Detailed Solution
Many antibiotics act by blocking a particular step of protein synthesis on the 70S ribosome of bacteria.
Neomycin is an aminoglycoside antibiotic. It binds to the 30S subunit and, according to the answer key of this paper, it inhibits the interaction between tRNA and mRNA (the codon-anticodon interaction).
Streptomycin, another aminoglycoside, inhibits the initiation of translation and causes misreading of the mRNA.
Erythromycin binds to the 50S subunit and inhibits the translocation of the ribosome along the mRNA.
Tetracycline inhibits the binding of aminoacyl-tRNA to the A site of the ribosome.
So the answer given is neomycin.
Neomycin is an aminoglycoside antibiotic. It binds to the 30S subunit and, according to the answer key of this paper, it inhibits the interaction between tRNA and mRNA (the codon-anticodon interaction).
Streptomycin, another aminoglycoside, inhibits the initiation of translation and causes misreading of the mRNA.
Erythromycin binds to the 50S subunit and inhibits the translocation of the ribosome along the mRNA.
Tetracycline inhibits the binding of aminoacyl-tRNA to the A site of the ribosome.
So the answer given is neomycin.