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Select the correct statements about sickle cell anaemia. (A) There is a change in gene for beta globin. (B) In the beta globin, there is valine in the place of Lysine. (C) It is an example of point mutation. (D) In the normal gene U is replaced by A. Choose the correct answer from the options given below:
A
(B), (C) and (D) only
B
(B) and (D) only
C
(A), (B) and (D) only
D
(A) and (C) only
Detailed Solution
Sickle cell anaemia results from a mutation in the gene for the beta chain of haemoglobin (A is correct), and this substitution is a classic example of a point mutation (C is correct). However, the actual substitution is valine replacing glutamic acid (not lysine, so B is incorrect), and it is the DNA base (not simply 'A' replacing 'U', which is an RNA-level statement rather than the correct DNA-level base change) — so D as stated does not correctly represent the mutation. Correct: A and C only.