Malonate inhibits the growth of pathogenic bacteria by inhibiting the activity of
A
Dinitrogenase
B
succinic dehydrogenase
C
Amylase
D
Lipase
The answer is B.
Solution
Malonate resembles succinate and competitively inhibits succinic dehydrogenase.
The competitive inhibitor competes with the substrate for the substrate binding site of the enzyme. Consequently, the substrate cannot bind and as a result, the enzyme action declines, e.g., inhibition of succinic dehydrogenase by malonate which closely resembles the substrate succinate in structure. Such competitive inhibitors are often used in the control of bacterial pathogens.
Conceptmalonate inhibits succinic dehydrogenase
Biomolecules in past papers
107 questions from this chapter have appeared across 26 exam years.
