A woman with normal vision, but whose father was colour blind, marries a colour blind man. Suppose that the fourth…

A woman with normal vision, but whose father was colour blind, marries a colour blind man. Suppose that the fourth child of this couple was a boy. This boy -
A Must have normal colour vision
B May be colour blind or may be of normal vision
C Will be partially colour blind since he is heterozygous for the colour blind mutant allele
D Must be colour blind

Detailed Solution

Colour blindness is an X-linked recessive trait. Let $X^c$ carry the allele for colour blindness.
The woman has normal vision, but her father was colour blind, so she received $X^c$ from him. She is a carrier: $X^cX$.
The colour blind man is $X^cY$.
A son receives the Y chromosome from his father and one X chromosome from his mother.
The mother gives either $X^c$ or $X$ with equal probability, so each son has a 50 percent chance of being $X^cY$ (colour blind) and a 50 percent chance of being $XY$ (normal).
The birth order of the child has no effect on this probability.
A male has only one X chromosome, so he cannot be heterozygous for this trait.
So the boy may be colour blind or may have normal vision.

Sex-linked inheritance in past papers

8 questions from this chapter have appeared across 6 exam years.

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Practise Sex-linked inheritance All 8 questions This chapter in 2005 AIPMT