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Coordination Compounds
Importance and Applications of Coordination Compounds
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Concepts tested
- Cisplatin as anticancer drug
All Questions
2004 AIPMT 1 question
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Which of the following is considered to be an anticancer species :-The anticancer drug cisplatin is cis-diamminedichloridoplatinum(II), cis-$[Pt(NH_3)_2Cl_2]$.
It is a square planar complex in which the two $NH_3$ ligands are adjacent (cis) and the two $Cl^-$ ligands are adjacent.
Inside the cell the Cl ligands are replaced by water, and the platinum binds to two neighbouring guanine bases of DNA. This cross-linking distorts the DNA and stops replication of the rapidly dividing cancer cells.
The trans isomer cannot bind to two neighbouring bases in this way and is not an effective anticancer drug.
$[PtCl_4]^{2-}$ and Zeise's salt anion $[PtCl_3(C_2H_4)]^-$ are not used as anticancer drugs.
So the anticancer species is the cis isomer of $[Pt(NH_3)_2Cl_2]$ (cisplatin).