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Molecular Basis of Inheritance
DNA Packaging and Chromosome Ends
1 question from 1 paper, each with its answer.
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Concepts tested
- G-rich telomeric repeats
All Questions
2004 AIPMT 1 question
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The telomeres of eukaryotic chromosomes consist of short sequences of -Telomeres are the protective ends of linear eukaryotic chromosomes.
They consist of many tandem repeats of a short DNA sequence. In humans and other vertebrates the repeat is TTAGGG, on the strand running 5' to 3' towards the end of the chromosome.
This strand is rich in guanine (three G in every six bases), and it forms a single-stranded G-rich overhang at the 3' end. Similar G-rich repeats occur in other eukaryotes (e.g. TTGGGG in Tetrahymena).
The enzyme telomerase, which carries its own RNA template, adds these G-rich repeats to the chromosome ends to prevent shortening at each replication.
So telomeres consist of short sequences of guanine rich repeats.