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Molecular Basis of Inheritance
RNA World
2 questions from 2 papers, each with its answer.
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- years asked, 2017–2026
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- of Molecular Basis of Inheritance
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Concepts tested
- Ribozymes and RNA world
- RNA vs DNA Evolution
All Questions
2025 1 question
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Given below are two statements:
Statement I: In the RNA world, RNA is considered the first genetic material evolved to carry out essential life processes. RNA acts as a genetic material and also as a catalyst for some important biochemical reactions in living systems. Being reactive, RNA is unstable.
Statement II: DNA evolved from RNA and is a more stable genetic material. Its double helical strands being complementary, resist changes by evolving repairing mechanism.
In the light of the above statements, choose the most appropriate answer from the options given below:Both statements correctly describe the RNA world and evolution of stable DNA.
RNA acted as both the initial genetic repository and biocatalyst. Due to 2'-OH groups, RNA is reactive and labile. DNA evolved via methylation (uracil to thymine) and deoxygenation into a double-stranded complementary helix with repair mechanisms, providing chemical and structural stability.
2001 AIPMT 1 question
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Due to discovery of which of the following in 1980, the evolution was termed as RNA world :In the early 1980s, Thomas Cech and Sidney Altman discovered that some RNA molecules can act as catalysts (ribozymes), e.g. self-splicing introns and RNase P.
This showed that RNA can both store genetic information and catalyse reactions.
So it was proposed that early life was based on RNA alone (the 'RNA world'), before DNA and protein enzymes evolved.
So the term RNA world came from the discovery that RNA has enzymatic properties.