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Molecular Basis of Inheritance
Post-transcriptional Processing: Splicing
1 question from 1 paper, each with its answer.
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Concepts tested
- Joining of exons
All Questions
2002 AIPMT 1 question
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Which of the following reunites the exon segments after RNA splicing : -In splicing, the introns are cut out of the primary transcript (hnRNA) and the exons are joined together to make the mature mRNA.
The joining of the cut ends of the exons is a ligation reaction (formation of a phosphodiester bond). In this question, the agent that reunites the exons is called RNA ligase.
(In eukaryotic nuclear mRNA, this is actually carried out by the spliceosome, made of snRNAs and proteins; a separate RNA ligase is used in tRNA splicing.)
So, as per the answer key, RNA ligase reunites the exon segments.