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Biotechnology and its Applications
Monoclonal Antibodies and Hybridoma Technology
1 question from 1 paper, each with its answer.
- question
- 1
- paper
- 1
- of Biotechnology and its Applications
- 1.16%
Concepts tested
- Hybridoma cells
All Questions
2001 AIPMT 1 question
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What is true for monoclonal antibodies : -Monoclonal antibodies are identical antibodies produced by a single clone of cells, and they are specific for one antigen (one epitope).
They are made by hybridoma technology (Kohler and Milstein, 1975): an antibody-producing B-lymphocyte (from a mouse immunised with the antigen) is fused with a myeloma (cancer) cell.
So the hybridoma cell is derived from two different parent cells: the B-cell provides the ability to make the specific antibody and the myeloma cell provides the ability to divide indefinitely.
So, as per the answer key, monoclonal antibodies are obtained from different parents (two fused parent cells) and are for one antigen.