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Principles of Inheritance and Variation

Chromosomal Basis of Genetic Disorders

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Matching Down's syndrome, thalassemias and Klinefelter's to affected chromosome

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2024 1 question

1 Principles of Inheritance and Variation Hard

Match List-I with List-II regarding genetic disorders and the chromosome involved.

Pick the matching item from Column II for each row.
Column I
- A. Down's syndrome Match for A
- B. $\alpha$-Thalassemia Match for B
- C. $\beta$-Thalassemia Match for C
- D. Klinefelter's Match for D
Column II
- I. 11th chromosome
- II. 'X' chromosome
- III. 21st chromosome
- IV. 16th chromosome
Correct answer: A → III, B → IV, C → I, D → II

Down's syndrome – additional copy of chromosome 21 (trisomy 21) $\alpha$-Thalassemia – controlled by two closely linked genes HBA1 and HBA2 on chromosome 16 $\beta$-Thalassemia – controlled by a single gene HBB on chromosome 11 Klinefelter's syndrome – additional copy of the X chromosome (47, XXY) Correct match: A-III, B-IV, C-I, D-II.